We have studied about the clinical effects of recently developed synthetic skin substitute, Biobrane, in burn wound.
We investigated quantitative changes of organisms, time length until complete epithelization occurs after application of the Biobrane in burned tissue & burn wounds, and analysed the results comparing to the control group treated conservatively without application of Biobrane.
And also investigated clinical characteristics of the Biobrane such as adherence, fluid collection under the Biobrane, relievability of pain, bleeding when remove it, flexibility and side effects.
We obtained following results:
1. The mean values for number of organisms/gm of burned tissues decreased to 2.5 ×10⁴96 hrs after application of Biobrane from 1.7 ×10?? before application(P＜0.05). In concontrol group, it was 4.6 ×10?? and there was no significant changes.
2. Epithelial proliferation were more rapid in Biobrane applied group than control group(P＜0.01).
3. Biobrane showed good adherence, excellent flexibility and relieved pain in majority of patients(90%) but in about 30% of patient, bothered them with bleeding when removed it.
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